PikeAngler
Would you like to react to this message? Create an account in a few clicks or log in to continue.

Lamprey article

+2
nickcarpy
Andy Webster
6 posters

Go down

Lamprey article Empty Lamprey article

Post  Andy Webster Wed Feb 02, 2011 9:28 pm

Next time you hook up a lamprey give a thought to their role in the evolution of man.

Lamprey Article

Andy

_________________
Andy Webster
www.pikeangler.co.uk
Andy Webster
Andy Webster

Posts : 1189
Join date : 2008-08-03
Age : 54
Location : Doncaster

http://www.pikeangler.co.uk

Back to top Go down

Lamprey article Empty Re: Lamprey article

Post  nickcarpy Wed Feb 02, 2011 9:38 pm

interesting pal, Very Happy Very Happy
nickcarpy
nickcarpy

Posts : 1717
Join date : 2008-11-03
Age : 51
Location : hatfield doncaster

Back to top Go down

Lamprey article Empty Re: Lamprey article

Post  esoxjeff Sat Feb 05, 2011 8:00 pm

Very interesting Cool
esoxjeff
esoxjeff

Posts : 1171
Join date : 2008-09-09
Location : Doncaster

Back to top Go down

Lamprey article Empty Re: Lamprey article

Post  Yorkshirepiker Fri Feb 11, 2011 6:44 pm

Interesting Shocked
Yorkshirepiker
Yorkshirepiker

Posts : 9
Join date : 2011-02-02

http://www.pacgb.com

Back to top Go down

Lamprey article Empty Re: Lamprey article

Post  tootall Fri Feb 11, 2011 6:59 pm

good article andy Smile
tootall
tootall

Posts : 1339
Join date : 2009-01-29
Age : 47
Location : Beverley, East Yorkshire

Back to top Go down

Lamprey article Empty Re: Lamprey article

Post  stubbo Fri Feb 11, 2011 8:14 pm

cant access the article andy Very Happy
stubbo
stubbo

Posts : 3976
Join date : 2010-01-14
Age : 61
Location : Warrington

Back to top Go down

Lamprey article Empty Text fro Lamprey Article

Post  Andy Webster Fri Feb 11, 2011 9:26 pm

This is the text from the article

Lampreys give clues to evolution of immune system
Biologists have discovered that primitive, predatory lampreys have structures within their gills that play the same role as the thymus, the organ where immune cells called T cells develop in mammals, birds and fish.

The finding suggests that in vertebrate evolution, having two separate organs for immune cell development -- the bone marrow for B cells and the thymus for T cells -- may have preceded the appearance of the particular features that mark those cells, such as antibodies and T cell receptors.

The results will be published Feb. 3 by the journal Nature.

The first author of the paper is postdoctoral fellow Baubak Bajoghli at the Max Planck Institute of Immunobiology and Epigenetics in Freiburg, Germany. The co-senior authors are Thomas Boehm, MD, group leader at the Max Planck Institute, and Max Cooper, MD, professor of pathology and laboratory medicine at Emory University School of Medicine and the Emory Vaccine Center, and a Georgia Research Alliance Eminent Scholar.

"Our research has allowed us to see that lampreys have cells that resemble our T cells and B cells, but until recently, we didn't know where they developed or much about how," says Cooper, who made pioneering studies of the "two-arm" nature of the immune system, including defining the role of the thymus, at the University of Minnesota in the 1960s.

"We can now assume that the lamprey has a dual immune defense system similar to that of humans," says Boehm.

For commercial and recreational fishermen, lampreys represent a threat. For biologists, lampreys represent an opportunity to envision the evolutionary past, because of their status as "living fossils" that haven't changed in millions of years. Lampreys are thought to be an early offshoot on the evolutionary tree, before sharks and fish. Their lack of jaws distinguishes them from sharks or other types of fish.

Despite their primitive nature, lampreys do have a surprisingly sophisticated immune system. Blood cells develop in lampreys' typhlosole, an organ that lies next to the intestine. Lampreys have proteins in their blood that grab on to invaders like our antibodies, but structurally, those proteins don't look like antibodies.

Mammals, birds and fish have two types of immune cells, which each develop in separate places. B cells, which produce antibodies, develop in the bone marrow and fetal liver, while T cells, which recognize their targets by cell-to-cell contact, develop in the thymus. In humans, the thymus is located in the upper chest, under the throat.

The vertebrate thymus is a place where developing T cells must "sink or swim," because immature T cells must rearrange certain genes as part of their development. Most of the cells die because the rearrangement process is imprecise, and cells with improperly rearranged genes are screened out. The Emory/Max Planck team discovered that this same type of screening of non-functional genes appears to be occurring in the lamprey "thymoids" located in the tips of the gill filament.

"We don't know much about how this process is happening, but we were able to show that functional copies are found in the blood, while non-functional copies are only found in the thymoid," Cooper says.

In addition, in cells lining both the vertebrate thymus and lamprey thymoid, a gene is turned on (FOXN1) that is essential for thymus development in mice and humans, the scientists found. Mice that have this gene mutated lack a thymus and are called "nude" mice because they have no hair.

"Taken together, the results suggest that this basic feature of the immune system, where two types of cells develop in separate places, may have evolved before jawed and jawless vertebrates split onto different paths," Cooper says. "Having two companion arms of the immune system may be important so that the two arms can regulate each other and prevent autoimmunity."


###

The research was supported by the Max-Planck Society, the German Research Foundation, the National Institutes of Health and the Georgia Research Alliance.


_________________
Andy Webster
www.pikeangler.co.uk
Andy Webster
Andy Webster

Posts : 1189
Join date : 2008-08-03
Age : 54
Location : Doncaster

http://www.pikeangler.co.uk

Back to top Go down

Lamprey article Empty Re: Lamprey article

Post  Andy Webster Fri Feb 11, 2011 9:29 pm

I'm not sure that I completely follow it but I get the gist... Lamprey are ancient...and humans have evolved from them; a long time ago mind.

Andy

_________________
Andy Webster
www.pikeangler.co.uk
Andy Webster
Andy Webster

Posts : 1189
Join date : 2008-08-03
Age : 54
Location : Doncaster

http://www.pikeangler.co.uk

Back to top Go down

Lamprey article Empty Re: Lamprey article

Post  stubbo Fri Feb 11, 2011 10:07 pm

Andy Webster wrote:I'm not sure that I completely follow it but I get the gist... Lamprey are ancient...and humans have evolved from them; a long time ago mind.

Andy
andy my brain cant access the article lol!
stubbo
stubbo

Posts : 3976
Join date : 2010-01-14
Age : 61
Location : Warrington

Back to top Go down

Lamprey article Empty Re: Lamprey article

Post  Andy Webster Fri Feb 11, 2011 10:34 pm

stubbo wrote:
Andy Webster wrote:I'm not sure that I completely follow it but I get the gist... Lamprey are ancient...and humans have evolved from them; a long time ago mind.

Andy
andy my brain cant access the article lol!

You're not the only one lol!

_________________
Andy Webster
www.pikeangler.co.uk
Andy Webster
Andy Webster

Posts : 1189
Join date : 2008-08-03
Age : 54
Location : Doncaster

http://www.pikeangler.co.uk

Back to top Go down

Lamprey article Empty Re: Lamprey article

Post  stubbo Fri Feb 11, 2011 10:39 pm

Andy Webster wrote:
stubbo wrote:
Andy Webster wrote:I'm not sure that I completely follow it but I get the gist... Lamprey are ancient...and humans have evolved from them; a long time ago mind.

Andy
andy my brain cant access the article lol!

You're not the only one lol!
mind you just glansing over at the missus i think i married one Shocked
stubbo
stubbo

Posts : 3976
Join date : 2010-01-14
Age : 61
Location : Warrington

Back to top Go down

Lamprey article Empty Re: Lamprey article

Post  Andy Webster Fri Feb 11, 2011 11:15 pm

What a Face

I couldn't possibly comment lol!

_________________
Andy Webster
www.pikeangler.co.uk
Andy Webster
Andy Webster

Posts : 1189
Join date : 2008-08-03
Age : 54
Location : Doncaster

http://www.pikeangler.co.uk

Back to top Go down

Lamprey article Empty Re: Lamprey article

Post  Sponsored content


Sponsored content


Back to top Go down

Back to top

- Similar topics

 
Permissions in this forum:
You cannot reply to topics in this forum